Santa Ana is the most populated city in Orange County, and the 53rd-most populous city in the entire US. The California Department of Finance put the city's 2009 census estimate at approximately 355,662.

The city is situated on flat, low-lying plains, with very little land elevation change. Now that the city is fully developed, Santa Ana can be divided into several distinct districts. The main core of the city, like any other, is the downtown area. Downtown contains retail and housing units, as well as the Santa Ana Civic Center, which is an area dedicated to administrative buildings for both the city and the Orange County. This area also contains the Ronald Reagan Federal Building and Courthouse.

There are a number of historical homes that can be found in the downtown area, some of which date back as late as the 1800s. Their preservation is a primary focus as the city continues to develop.

North of the downtown area is the "Midtown" district that is found along Main St. Midtown is home to a number of popular entertainment destinations like the Bowers Museum, MainPlace Mall, and the Discovery Science Center.

The new "Metro East" area has been designated as a secondary mix-use development district. Currently the area contains a number of office towers, but there have been plans made to make this place into a fine retail establishment.

On the east side of the city is the Santa Ana Zoo, which is famous for its collection of monkeys and animals from South and Central America. The South end of the city is part of the South Coast Metro area. The South Coast Plaza is a very popular shopping center and is the primary destination of the area. Here you can also find a number of high-rise offices and apartment buildings that are perfect for those looking for a home close to the local retailers.

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